Boosting Synaptic Transmission with Pyridine and Nicotinamide Derivatives

In the proposed project, our team aims to investigate the use of newly synthesized compounds based on pyridine and nicotinamide structures (3-hydroxy-2-pyridines and derivatives of vitamins B6 and B3) as bioactive agents in modulating neurotransmission.

We will determine the cytotoxicity, myotoxicity, and genotoxicity of the tested compounds to eliminate those with potential adverse effects and reduce the costs of future preclinical studies. Using the obtained results, we will conduct a structure-activity relationship analysis and, by applying a medicinal chemistry approach, predict new compounds with improved efficacy, selectivity, and safety profiles. Through this multidisciplinary approach, we will gain a comprehensive picture of our compounds' activity across three interconnected neurotransmission systems—cholinergic, glutamatergic, and serotonergic—and draw conclusions regarding their potential as drugs for modulating neurotransmission.